Milne Institute Current Research

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Current Research

Click the links for research details. 

A descriptive study based on retrospective analysis of patients recovering for Covid-19 at Gaylord Hospital. Demographics and functional status to be descried and compared to a cohort population so establish a baseline for other institutions in their clinical decision making models.

A randomized controlled trial on the effectiveness of the ZeroG body weight support system TRiP program in acute stroke patients.  A comparison of the standard ZeroG training group and the TRiP group utilizing objective balance scales and self-assessment.

A randomized control trial on patients diagnosed with acute neurological visual impairment. The aim of this study is to compare BITS touch screen technology with traditional tabletop activities and their effectiveness at improving visual field awareness.

A study to evaluate the natural history of a stroke using a low field MRI (Hyperfine).  Stroke patients are scanned shortly after admission and then every 5-7 days until discharge to track the progression of a stoke using low field, portable MRI technology. This information is also compared to standard outcomes measures to determine how these correlate with the progression of the stroke seen in the MRI images.

Safety, Efficacy and tolerability of BAF312 in patients with stroke due to intracerebral hemorrhage: A double blind, randomized, placebo-controlled phase II trial for Novartis (siponimod) in patients with intracerebral hemorrhage

AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke, a.k.a. ARCADIA: A multicenter, randomized, double-blind, active-control study to compare the effects of apixaban versus aspirin in patients with unexplained ischemic stroke and atrial cardiopathy to see which is better at prevention of future strokes

Anticoagulation in Intracerebral Hemorrhage (ICH) Survivors for Stroke Prevention and Recovery (ASPIRE): This study is a randomized, double-blinded, phase III clinical trial designed to test the efficacy and safety of anticoagulation, compared with aspirin, in patients with a recent ICH and high-risk non-valvular atrial fibrillation/flutter (AF).

TOPS - Take Off Pounds After Stroke: A study post ischemic stroke participants to determine if a 12-week partial meal replacement program, compared to dietary counseling, can result in weight loss after stroke without affecting physical function.

Gaylord Specialty Healthcare is a partner in the Spaulding New England Regional Spinal Cord Injury Center (SNERSCIC). The overall goal of SNERSCIC is to provide a multidisciplinary comprehensive system of care for individuals with SCI as a basis for conducting research that extends the existing evidence base for SCI rehabilitation. Our focus is health, function and technology, especially for the most vulnerable, to empower individuals with SCI to lead fulfilling and meaningful lives.

As a partner site in the Model System, we conduct some SCI Model System studies:

The National Spinal Cord Injury Database Project

The purpose of this core study is to allow healthcare professionals and researchers to evaluate trends over time for many aspects of SCI to improve rehabilitation services and help people with SCI live the best they can in the community.  Data collection begins during the inpatient rehabilitation stay, is updated approximately one year after injury, and every five years thereafter.  No medical procedures are involved and information is gathered through a one-on-one interview by phone or in person.

If you believe you are enrolled in the study, please contact Diana Pernigotti at 203-679-3563 or [email protected] for information regarding your follow up status or to update your contact information.

Equity and Quality in Assistive Technology (EQuATe) 2.0 for Individuals with Spinal Cord Injury

Gaylord is joining eight other Model Systems nationwide, led by the University of Pittsburgh, to explore wheelchair equipment and services provided to individuals with SCI of different ethnic, economic, and social backgrounds. The goal of this study is to improve the quality of wheelchairs prescribed for individuals with SCI. In addition, the proposed research may benefit all individuals who use manual wheelchairs and power wheelchairs in the future, given recent changes in health care policy of competitive bidding that limit financial reimbursement for medical services and supplies. The impact of changes in coverage are likely to be profound, but can only be measured if they are tracked.

For this study, we will collect information on Assistive Technology (AT) used by individuals with SCI, specifically wheelchair make, model, failures, and repairs. This data will enable us to track the impact of insurance market changes, find differences in wheelchair failures, and present this information to wheelchair users. This study also collects information regarding any perceived prejudices you may have experienced in your healthcare system.

For more information, including a consent form for the study, contact Diana Pernigotti at 203-679-3563 or [email protected]

Development and Validation of the SCI-Functional Index/Assistive Technology  (SCI-FI/AT) Inpatient Short Forms

The SCI-FI instrument was designed specifically for persons with SCI, regardless of level or severity of injury. The content of the SCI-FI is based upon an extensive review of the literature, input from patients with SCI, and clinician focus groups, and is grounded within the International Classification of Function, Disability, and Health framework.

With the development of the SCI-FI/AT, we now have available SCI-FI scales that evaluate a person’s ability to function using adaptive technology in the areas of Basic Mobility, Self-Care, Ambulation, Fine Motor, and Wheelchair function. There are 178 total items in the final SCI- FI/AT domain item banks. Short forms are aptly named as a short paper-based version of the full item banks of each functional domain of the SCI-FI/AT, which is currently administered via computer as a computer adaptive test (CAT).

Aim 1 –Create a SCI-FI/AT inpatient short form that can be completed efficiently by clinicians on patients while they are in the inpatient rehabilitation setting.

Aim 2 – We will conduct a pilot study to evaluate the inter-rater reliability of having clinicians complete the SCI-FI/AT inpatient short forms with a sample of patients in the SNERSCIC SCIMS network.

This study involves inpatient clinicians and they will be asked individually for participation. For more information about the development of the SCI-FI over the past 10 years. Read about previous SCI-FI studies here.

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